{
  "frame": "sniff:frame/human-disease-gene-canine-model",
  "question": "Does a canine model foundation exist for this human disease gene under ClinVar 3-star review plus an assertable one-to-one ortholog?",
  "subject": "HGNC:SOD1",
  "subject_symbol": "SOD1",
  "predicate": "biolink:model_of",
  "sources_checked": [
    "infores:clinvar",
    "infores:ensembl-gene"
  ],
  "scope": {
    "measures": "This frame measures ClinVar 3-star review reach into canine models via dog orthology, not the canine literature.",
    "sources_queried": [
      "infores:clinvar",
      "infores:ensembl-gene"
    ],
    "sources_not_queried": [
      {
        "source": "infores:omia",
        "reason": "OMIA is the authority on documented canine Mendelian disease. This frame's answered predicate is ClinVar 3-star pathogenic or likely pathogenic plus an assertable dog ortholog, so OMIA was not queried.",
        "close_path": "Publish a parallel OMIA-scoped frame over the same subject axis (sniff:frame/human-disease-gene-canine-model/omia). Do not join OMIA into this frame's answered predicate. Narrowness is the measurement."
      }
    ]
  },
  "as_of": "2026-08-13",
  "frame_context": {
    "expected_cardinality": 16754,
    "answered": 124,
    "dark": 16630,
    "dark_by_cause": {
      "no_disease_anchor": 11161,
      "below_bar": 5362,
      "unreachable": 107
    }
  },
  "provenance": "sniff:release/2026-09-04#sha256:dd107378f6969b02a55103552f3674277b3d190024a5d22ee9d42055bacedeeb",
  "canonical_url": "https://sniff.world/frontier/",
  "lookup_url": "https://sniff.world/lookup/",
  "stack": {
    "by_frame": {
      "sniff:frame/human-disease-gene-canine-model": {
        "status": "dark",
        "cause": "below_bar"
      },
      "sniff:frame/human-disease-gene-canine-model/omia": {
        "status": "answered",
        "cause": null
      }
    },
    "intersection": "lit_any",
    "as_of_by_frame": {
      "sniff:frame/human-disease-gene-canine-model": "2026-08-13",
      "sniff:frame/human-disease-gene-canine-model/omia": "2026-08-27"
    }
  },
  "in_universe": true,
  "status": "dark",
  "cause": "below_bar",
  "cause_definition": "human P/LP signal exists but sits below the 3-star expert-panel review bar in ClinVar",
  "reason": "human P/LP anchor exists but below the 3-star expert-review bar",
  "ensembl_gene_id": "ENSG00000142168",
  "message": "No canine model foundation under this frame's criteria (ClinVar 3-star + one-to-one ortholog). Cause: below_bar. Human P/LP signal exists but sits below the 3-star expert-panel review bar in ClinVar. Evidence outside these sources is out of scope for this frame."
}