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Canine gene

F8

Human counterpart: F8

F8 is a gene catalogued in the canine genome. Below are the inherited conditions OMIA links to it in dogs, its human counterpart, and its canonical records across the genomics world.

Conditions linked to this gene

The inherited conditions OMIA associates with F8 in dogs. Each links to the full record.

In the reference databases

F8 as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.

The human counterpart

In humans, this gene's counterpart is F8. That ortholog is what connects F8 to a century of human medical genetics. The dog and human proteins are 77% identical.

In people, variants in the F8 gene are classified as pathogenic in ClinVar for 1 expert-reviewed condition.

Translational evidence balance
balanced · 0

Dog and human evidence are symmetric here, a validated cross-species footprint. Coverage, not importance. D = 1 dog vs H = 1 human cited disease channels.

Medicine face

Q1 · both planes filled

F8

Two planes on one gene. Disagreement is the reading, not a hole to fill.A teaching case. Both the canine evidence plane and the human medicine plane hold a row.

Canine plane

Coverage

answered

lit_all

Spectra

7 named streams agree. A recount, not a medicine vote.

Open Spectra

Lookup · Discovery · Frontier

Lookup abstained. Discovery recovered known. A candidate never fills a drug row. Frontier is not the subject here.

Medicine plane

Mechanism

Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.

Source UniProt via Open Targets

Defective F8 accelerates dissociation of the A2 domain · Initiation of coagulation cascade · Platelet degranulation · Cargo concentration in the ER · Defective factor IX causes thrombophilia · Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation · Reactome

Molecules

  • Giroctocogene Fitelparvovec

    PHASE 3

    EXOGENOUS GENE · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

    Labeled for hemophilia A.

  • Adynovi, generically Antihemophilic Factor, Pegylated (Mw 20000) Human Sequence Recombinant

    APPROVAL

    EXOGENOUS PROTEIN · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

    Labeled for hemophilia A.

  • Jivi, generically Damoctocog Alfa Pegol

    APPROVAL

    EXOGENOUS PROTEIN · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

    Labeled for hemophilia A.

  • Altuviiio, generically Efanesoctocog Alfa

    APPROVAL

    EXOGENOUS PROTEIN · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

    Labeled for hemophilia A.

Drotrecogin Alfa (Activated) and Tb-402 act on this protein and are labeled for other conditions. Acting on a protein is not treating a disease of it.

More molecule rows are held. This face does not print an approved-drug count.

Canine trials

unqueryable

We hold no canine registry row. The AVMA Veterinary Clinical Trials Registry is the index that would hold one. This station is unqueryable until that ingest exists. That is not evidence that nobody runs trials in dogs.

PK / tox station

stub

This station is not wired. No PK or tox numbers.

This is not a treatment recommendation and not a claim about any individual dog.

Molecule direction and mechanism of action include ChEMBL (CC BY-SA 3.0).

Coverage · Spectra · Frontier

Research tools for this gene
Dog10K lookup Candidate models AVCG classification table

Lookup and discovery are candidate-framed research surfaces. Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.

On the numbers

Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For F8 we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.

How to cite this page

Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.

Last updated
Sources: OMIA · Sniff gene crossrefs · Ensembl / NCBI / HGNC · ClinVar (Landrum 2018)