156 disease records with breed allele frequencies
Every OMIA-catalogued canine Mendelian disease with allele-frequency data in the Sniff Atlas. Sorted by number of breeds with observed carriers, so the diseases that segregate most broadly surface first. Frequencies are from the Donner 2023 cohort; penetrance data is included where the Sniff Atlas v1.0.2 has it (45 of 156).
An allele frequency is the share of tested gene copies carrying the variant, not the share of dogs and not disease incidence. Predicted disease relevance at the per-dog level is UNPROVEN; outcome depends on penetrance, modifier loci, and environment. Consult a veterinarian for clinical interpretation.
Breadth versus peak frequency
Every record at once: how many breeds carry it, against the highest allele frequency seen in any one breed. The broad, common ones sit top-right; the long tail of rare, breed-restricted variants gathers bottom-left. Tap any dot to open it.
Degenerative Myelopathy (DM)
Autosomal recessive (Incomplete penetrance). Observed in 138 of 266 breeds tested , top: Fox Terrier Wire at 82.4%.
Chondrodystrophy and Intervertebral Disc Disease Risk (CDDY)
Autosomal dominant. Observed in 113 of 266 breeds tested , top: Bavarian Mountain Hound at 100.0%.
Dilated Cardiomyopathy risk factor (Discovered in the Doberman Pinscher; PDK4-related)
Autosomal dominant (Incomplete penetrance). Observed in 97 of 266 breeds tested , top: Lowchen at 75.0%.
Progressive Rod-Cone Degeneration (prcd-PRA)
Autosomal recessive. Observed in 79 of 266 breeds tested , top: Australian Cattle Dog at 30.7%.
Cone-Rod Dystrophy (cord1-PRA/crd4)
Autosomal recessive (Incomplete penetrance). Observed in 75 of 266 breeds tested , top: Bulgarian Shepherd at 50.0%.
Cystinuria Type I-B (SLC7A9 p.A217T)
Autosomal recessive (Incomplete penetrance). Observed in 64 of 266 breeds tested , top: Bulldog Standard at 55.5%.
Hyperuricosuria (HUU)
Autosomal recessive. Observed in 61 of 266 breeds tested , top: Dalmatian at 92.7%.
Von Willebrand's Disease, Type 1 (vWD 1)
Autosomal recessive. Observed in 60 of 266 breeds tested , top: Dobermann Pinscher at 36.5%.
Cystinuria Type I-A (SLC3A1 p.I192V)
Autosomal recessive. Observed in 50 of 266 breeds tested , top: Shikoku Ken at 75.0%.
Collie Eye Anomaly (CEA)
Autosomal recessive. Observed in 44 of 266 breeds tested , top: Collie at 72.2%.
Factor VII Deficiency
Autosomal recessive. Observed in 41 of 266 breeds tested , top: Sealyham Terrier at 25.0%.
Primary Lens Luxation (PLL)
Autosomal recessive. Observed in 38 of 266 breeds tested , top: Volpino Italiano at 23.5%.
Canine Multifocal Retinopathy 1 (Discovered in Mastiff-related breeds; CMR1)
Autosomal recessive. Observed in 37 of 266 breeds tested , top: Boerboel at 29.7%.
Exercise-Induced Collapse (EIC)
Autosomal recessive (Incomplete penetrance). Observed in 36 of 266 breeds tested , top: Curly Coated Retriever at 42.9%.
Bald Thigh Syndrome (Discovered in Sighthounds)
Autosomal recessive. Observed in 32 of 211 breeds tested , top: Borzoi at 100.0%.
MDR1 (Multidrug Resistance 1) Medication Sensitivity
Autosomal dominant. Observed in 30 of 266 breeds tested , top: Collie at 56.4%.
Early-Onset Progressive Polyneuropathy (Discovered in the Greyhound)
Autosomal recessive. Observed in 26 of 266 breeds tested , top: Alaskan Malamute at < 1%.
Acral Mutilation Syndrome (AMS)
Autosomal recessive. Observed in 22 of 266 breeds tested , top: Cirneco Del Etna at 14.3%.
Pituitary-Dependent Hyperadrenocorticism (Discovered in Poodles)
Autosomal dominant. Observed in 22 of 266 breeds tested , top: Bracco Italiano at 12.5%.
Craniomandibular Osteopathy (Discovered in the Cairn, Scottish and West Highland White Terrier)
Autosomal dominant (Incomplete penetrance). Observed in 18 of 266 breeds tested , top: West Highland White Terrier at 24.5%.
Progressive Retinal Atrophy (Discovered in the Giant Schnauzer; NECAP1-related)
Autosomal recessive. Observed in 18 of 266 breeds tested , top: Dachshund Shorthaired at 25.0%.
Ichthyosis (Discovered in the Golden Retriever)
Autosomal recessive. Observed in 17 of 266 breeds tested , top: Golden Retriever at 27.5%.
Hypocatalasia
Autosomal recessive. Observed in 16 of 266 breeds tested , top: American Foxhound at 14.8%.
Macrothrombocytopenia (Discovered in the Norfolk and Cairn Terrier)
Autosomal recessive. Observed in 16 of 266 breeds tested , top: Norfolk Terrier at 47.1%.
Stargardt Disease (Discovered in the Labrador Retriever)
Autosomal recessive. Observed in 13 of 266 breeds tested , top: Labrador Retriever at 11.2%.
Amelogenesis Imperfecta (Discovered in the Parson Russell Terrier; AI)
Autosomal recessive. Observed in 12 of 266 breeds tested , top: Italian Greyhound at 22.6%.
Prekallikrein Deficiency
Autosomal recessive. Observed in 12 of 266 breeds tested , top: Shih Tzu at 10.5%.
Skeletal Dysplasia 2 (SD2)
Autosomal recessive. Observed in 12 of 266 breeds tested , top: Sussex Spaniel at 100.0%.
Dental Hypomineralisation (Discovered in the Border Collie)
Autosomal recessive. Observed in 11 of 266 breeds tested , top: Border Collie at 1.1%.
Polyneuropathy with Ocular Abnormalities and Neuronal Vacuolation (Discovered in the Black Russian Terrier and Rottweiler; POANV)
Autosomal recessive. Observed in 11 of 266 breeds tested , top: Black Russian Terrier at 8.7%.
Canine Scott Syndrome (CSS)
Autosomal recessive. Observed in 10 of 266 breeds tested , top: Presa Canario at 1.6%.
Dilated Cardiomyopathy (Discovered in the Schnauzer; DCM)
Autosomal recessive. Observed in 10 of 266 breeds tested , top: Schnauzer Standard at 3.3%.
Protein Losing Nephropathy (PLN; NPHS1-related)
Autosomal recessive (Incomplete penetrance). Observed in 10 of 266 breeds tested , top: Soft Coated Wheaten Terrier at 18.0%.
Shar-Pei Autoinflammatory Disease (SPAID)
Autosomal dominant (Incomplete penetrance). Observed in 10 of 266 breeds tested , top: Chinese Shar Pei at 67.0%.
Bleeding disorder (Discovered in the Greater Swiss Mountain Dog; P2RY12-related)
Autosomal recessive. Observed in 9 of 266 breeds tested , top: Greater Swiss Mountain Dog at 21.2%.
Congenital Myasthenic Syndrome (Discovered in the Heideterrier; CHRNE-related; CMS)
Autosomal recessive. Observed in 9 of 266 breeds tested , top: Fox Terrier Smooth at 12.5%.
Ehlers-Danlos Syndrome (Discovered in the Chihuahua and Poodle)
Autosomal recessive. Observed in 9 of 211 breeds tested , top: Miniature Pinscher at 50.0%.
Osteochondrodysplasia (Discovered in the Miniature Poodle)
Autosomal recessive. Observed in 9 of 266 breeds tested , top: Papillon at 4.6%.
Chondrodysplasia, Disproportionate Short-limbed (Discovered in the Norwegian Elkhound; ITGA10-related)
Autosomal recessive. Observed in 8 of 266 breeds tested , top: Chinook at 14.0%.
Cystinuria Type II-A (Discovered in the Australian Cattle Dog)
Autosomal dominant. Observed in 8 of 266 breeds tested , top: Australian Cattle Dog at 2.3%.
Intestinal Cobalamin Malabsorption (Discovered in the Border Collie; CUBN-related)
Autosomal recessive. Observed in 8 of 266 breeds tested , top: Komondor at 17.9%.
Neuronal Ceroid Lipofuscinosis 4A (Discovered in the American Staffordshire Terrier; NCL4A)
Autosomal recessive. Observed in 8 of 266 breeds tested , top: American Staffordshire Terrier at 3.4%.
Centronuclear Myopathy (Discovered in the Labrador Retriever; HACD1-related; CNM)
Autosomal recessive. Observed in 7 of 266 breeds tested , top: Labrador Retriever at 1.0%.
Hereditary Footpad Hyperkeratosis (Discovered in the Irish Terrier and Kromfohrländer)
Autosomal recessive. Observed in 7 of 266 breeds tested , top: Bedlington Terrier at 13.6%.
Musladin-Lueke syndrome (MLS)
Autosomal recessive. Observed in 7 of 266 breeds tested , top: Beagle at 1.7%.
Neuroaxonal Dystrophy (Discovered in the Rottweiler; VPS11-related)
Autosomal recessive. Observed in 7 of 266 breeds tested , top: Rottweiler at 3.0%.
Progressive Retinal Atrophy (Discovered in the Golden Retriever; GR_PRA2)
Autosomal recessive. Observed in 7 of 266 breeds tested , top: Golden Retriever at 2.8%.
Progressive Retinal Atrophy (Discovered in the Swedish Vallhund; MERTK-related)
Autosomal recessive. Observed in 7 of 266 breeds tested , top: Swedish Vallhund at 43.8%.
Spinocerebellar Ataxia with Myokymia and/or Seizures (KCNJ10-related; SCA)
Autosomal recessive. Observed in 7 of 266 breeds tested , top: Fox Terrier Toy at 3.1%.
Congenital Dyshormonogenic Hypothyroidism with Goiter (Discovered in the Shih Tzu)
Autosomal recessive. Observed in 6 of 266 breeds tested , top: Pekingese at 1.0%.
Congenital Hypothyroidism (Discovered in the Toy Fox and Rat Terrier)
Autosomal recessive. Observed in 6 of 266 breeds tested , top: Fox Terrier Toy at 4.2%.
Deafness and Vestibular Dysfunction (Discovered in the Doberman Pinscher)
Autosomal recessive. Observed in 6 of 266 breeds tested , top: Mudi at 4.8%.
Hereditary Nasal Parakeratosis (Discovered in the Labrador Retriever; HNPK)
Autosomal recessive. Observed in 6 of 266 breeds tested , top: Saluki at 4.2%.
Neuronal Ceroid Lipofuscinosis 8 (Discovered in the Australian Shepherd; NCL8)
Autosomal recessive. Observed in 6 of 266 breeds tested , top: Gordon Setter at 5.0%.
Persistent Müllerian Duct Syndrome (PMDS)
Autosomal recessive. Observed in 6 of 266 breeds tested , top: Schnauzer Miniature at 9.4%.
Progressive Retinal Atrophy (Discovered in the Golden Retriever; GR_PRA1)
Autosomal recessive. Observed in 6 of 266 breeds tested , top: Golden Retriever at 1.6%.
Acute Respiratory Distress Syndrome (Discovered in the Dalmatian; ARDS)
Autosomal recessive. Observed in 5 of 266 breeds tested , top: Bloodhound at < 1%.
Cone Degeneration (Discovered in the Alaskan Malamute)
Autosomal recessive. Observed in 5 of 266 breeds tested , top: Alaskan Malamute at < 1%.
Episodic Falling (EF)
Autosomal recessive. Observed in 5 of 266 breeds tested , top: Cavalier King Charles Spaniel at 6.7%.
Fanconi Syndrome
Autosomal recessive. Observed in 5 of 266 breeds tested , top: Basenji at 11.2%.
Glycogen storage disease VII (GSD VII) or Phosphofructokinase (PFK) Deficiency
Autosomal recessive. Observed in 5 of 266 breeds tested , top: English Springer Spaniel at 1.9%.
Ichthyosis (Discovered in the American Bulldog; NIPAL4-related)
Autosomal recessive. Observed in 5 of 266 breeds tested , top: Bulldog American at 9.1%.
Neuronal Ceroid Lipofuscinosis 5 (Discovered in the Border Collie; NCL5)
Autosomal recessive. Observed in 5 of 266 breeds tested , top: Australian Cattle Dog at 1.5%.
Progressive Retinal Atrophy (Discovered in the Shetland Sheepdog; CNGA1-PRA)
Autosomal recessive. Observed in 5 of 265 breeds tested , top: Shetland Sheepdog at < 1%.
Pyruvate Kinase (PK) Deficiency (Discovered in the Beagle)
Autosomal recessive. Observed in 5 of 266 breeds tested , top: Beagle at < 1%.
Rod-Cone Dysplasia 1a (Discovered in the Sloughi; rcd1a)
Autosomal recessive. Observed in 5 of 266 breeds tested , top: Kooikerhondje at < 1%.
Rod-Cone Dysplasia 3 (Discovered in the Cardigan Welsh Corgi; rcd3)
Autosomal recessive. Observed in 5 of 266 breeds tested , top: Chinese Crested at 1.5%.
Van den Ende-Gupta Syndrome (VDEGS)
Autosomal recessive. Observed in 5 of 266 breeds tested , top: Fox Terrier Wire at 20.8%.
Complement 3 (C3) Deficiency
Autosomal recessive. Observed in 4 of 266 breeds tested , top: Brittany at < 1%.
Familial Nephropathy (Discovered in the English Cocker Spaniel; FN)
Autosomal recessive. Observed in 4 of 266 breeds tested , top: Welsh Springer Spaniel at 4.2%.
Narcolepsy (Discovered in the Labrador Retriever)
Autosomal recessive. Observed in 4 of 266 breeds tested , top: Labrador Retriever at < 1%.
Neuronal Ceroid Lipofuscinosis 12 (Discovered in the Australian Cattle Dog)
Autosomal recessive. Observed in 4 of 265 breeds tested , top: Australian Cattle Dog at 1.2%.
Thrombopathia (Discovered in the Eskimo Spitz)
Autosomal recessive. Observed in 4 of 266 breeds tested , top: Basset Hound at 1.3%.
Xanthinuria, Type II (Discovered in the Cavalier King Charles Spaniel)
Autosomal recessive. Observed in 4 of 266 breeds tested , top: Manchester Terrier Toy at 4.2%.
Bardet-Biedl syndrome 2 or Progressive Retinal Atrophy (Discovered in the Shetland Sheepdog; BBS2-PRA)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Shetland Sheepdog at 2.1%.
Cerebellar Ataxia (Discovered in the Old English Sheepdog and the Gordon Setter)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Old English Sheepdog at 3.8%.
Deafness and Vestibular Dysfunction (Discovered in the Doberman Pinscher; PTPRQ-related)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Dobermann Pinscher at < 1%.
Dystrophic Epidermolysis Bullosa (Discovered in the Golden Retriever)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Rhodesian Ridgeback at < 1%.
Focal Non-Epidermolytic Palmoplantar Keratoderma (Discovered in the Dogue de Bordeaux)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Dogue De Bordeaux at 1.5%.
Globoid Cell Leukodystrophy (Discovered in Terriers)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Cairn Terrier at < 1%.
Microphthalmia (Discovered in the Soft-Coated Wheaten Terrier)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Russell Terrier at 6.5%.
Mucopolysaccharidosis, Type VII (Discovered in the German Shepherd Dog; MPS VII)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Terrier Brazileiro at 10.0%.
Muscular Dystrophy, Ullrich Type (Discovered in the Landseer)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Landseer at 25.0%.
Oculoskeletal Dysplasia (OSD2)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Samoyed at 1.2%.
Primary Open Angle Glaucoma (Discovered in Basset Fauve de Bretagne; ADAMTS17-related; POAG)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Basset Griffon Vendeen Petit at 25.0%.
Primary Open Angle Glaucoma (Discovered in the Beagle; POAG)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Laika at 8.3%.
Progressive Retinal Atrophy (Discovered in the Lapponian Herder; IFT122-PRA)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Lapponian Herder at 15.4%.
Progressive Retinal Atrophy (Discovered in the Lhasa Apso; IMPG2-related PRA4)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Lhasa Apso at < 1%.
Rod-Cone Dysplasia 1 (Discovered in the Irish Setter; rcd1)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Irish Setter at 1.2%.
Sensory Neuropathy (Discovered in the Border Collie)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Border Collie at < 1%.
Spongy Degeneration with Cerebellar Ataxia (Discovered in the Belgian Malinois; ATP1B2-related SDCA2)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Belgian Malinois at 4.4%.
Von Willebrand's Disease, Type 3 (Discovered in the Shetland Sheepdog; vWD 3)
Autosomal recessive. Observed in 3 of 266 breeds tested , top: Scottish Terrier at 1.3%.
Bandera's Neonatal Ataxia (BNAt)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Coton De Tulear at 2.4%.
Canine Multifocal Retinopathy 2 (Discovered in the Coton de Tulear; CMR2)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Coton De Tulear at 4.8%.
Canine Multifocal Retinopathy 3 (Discovered in the Lapponian Herder; CMR3)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Lapponian Herder at 13.5%.
Cone-Rod Dystrophy 1 (Discovered in the American Staffordshire Terrier; crd1)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: American Staffordshire Terrier at 1.0%.
Cone-Rod Dystrophy 2 (Discovered in the Pit Bull Terrier; crd2)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: American Staffordshire Terrier at < 1%.
Congenital Myasthenic Syndrome (Discovered in the Labrador Retriever)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Labrador Retriever at < 1%.
Glanzmann Thrombasthenia, Type I (Discovered in the Great Pyrenees)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Great Pyrenees at < 1%.
Glycogen Storage Disease, Type Ia (GSD Ia)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Maltese at < 1%.
GM1 Gangliosidosis (Discovered in the Shiba)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Portuguese Water Dog at < 1%.
Hereditary Elliptocytosis
Autosomal dominant. Observed in 2 of 266 breeds tested , top: Golden Retriever at < 1%.
Hypomyelination (Discovered in the Weimaraner)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Weimaraner at < 1%.
Lethal Acrodermatitis (Discovered in the Bull Terrier; LAD)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Bull Terrier Standard at 7.4%.
Lung Developmental Disease (Discovered in the Airedale Terrier)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Airedale Terrier at 2.8%.
Myeloperoxidase Deficiency (Discovered in the Italian Hound)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Beagle at < 1%.
Myotonia Congenita (Discovered in the Australian Cattle Dog)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Border Collie at < 1%.
Neonatal Cerebellar Cortical Degeneration (SPTBN2-related; NCCD)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Beagle at < 1%.
Neuronal Ceroid Lipofuscinosis 7 (Discovered in the Chinese Crested Dog and Chihuahua; NCL7)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Chihuahua at < 1%.
Nonsyndromic hearing loss (Discovered in the Rottweiler)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Rottweiler at < 1%.
Osteogenesis Imperfecta (Discovered in the Dachshund; OI)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Dachshund Miniature Shorthaired at < 1%.
Pituitary Dwarfism (Discovered in the Karelian Bear Dog; POU1F1-related)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Karelian Bear Dog at 4.4%.
Polycystic Kidney Disease (Discovered in the Bull Terrier)
Autosomal dominant. Observed in 2 of 266 breeds tested , top: Labrador Retriever at < 1%.
Primary Ciliary Dyskinesia (Discovered in the Alaskan Malamute; NME5-related; PCD)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Alaskan Malamute at 1.4%.
Primary Ciliary Dyskinesia (Discovered in the Old English Sheepdog; CCDC39-related PCD)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Old English Sheepdog at 1.4%.
Progressive Retinal Atrophy (Discovered in the Papillon and Phalène; CNGB1-related; PAP1_PRA)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Brussels Griffon at 1.7%.
Trapped Neutrophil Syndrome (TNS)
Autosomal recessive. Observed in 2 of 266 breeds tested , top: Border Collie at 2.8%.
Benign Familial Juvenile Epilepsy (Discovered in the Lagotto Romagnolo; BFJE)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Lagotto Romagnolo at 12.7%.
Canine Leukocyte Adhesion Deficiency (CLAD), Type III
Autosomal recessive. Observed in 1 of 266 breeds tested , top: German Shepherd at < 1%.
Canine Multiple Systems Degeneration (Discovered in the Chinese Crested Dog; CMSD)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Chinese Crested at < 1%.
Centronuclear Myopathy (Discovered in the Great Dane; BIN1-related; CNM)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Great Dane at < 1%.
Cleft Lip with/without Palate and Syndactyly (ADAMTS20-related)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Nova Scotia Duck Tolling Retriever at 4.8%.
Cleft Palate (DLX6-related)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Nova Scotia Duck Tolling Retriever at < 1%.
Congenital Cornification Disorder (Discovered in the Chihuahua)
X-linked semi-dominant. Observed in 1 of 211 breeds tested , top: Azawakh at 11.5%.
Craniomandibular Osteopathy (Discovered in the Weimaraner; CMO)
Autosomal dominant. Observed in 1 of 211 breeds tested , top: Weimaraner at 16.1%.
Dandy-Walker-Like Malformation (Discovered in the Eurasier; DWLM)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Eurasier at 10.5%.
Demyelinating Polyneuropathy (Discovered in the Miniature Schnauzer; SBF2-related)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Schnauzer Miniature at < 1%.
Dominant Progressive Retinal Atrophy (DPRA)
Autosomal dominant. Observed in 1 of 266 breeds tested , top: Mastiff at < 1%.
Early-onset PRA (Discovered in the Portuguese Water Dog; EOPRA)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Portuguese Water Dog at < 1%.
Glycogen Storage Disease, Type IIIa (GSD IIIa)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Curly Coated Retriever at 6.3%.
GM2 Gangliosidosis (Discovered in the Japanese Chin)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Japanese Chin at 3.2%.
Hemophilia A (Discovered in the German Shepherd Dog; F8 p.C548Y)
X-linked recessive. Observed in 1 of 266 breeds tested , top: German Shepherd at < 1%.
Hereditary Ataxia (Discovered the in Belgian Malinois; SLC12A6-related)
Autosomal recessive. Observed in 1 of 211 breeds tested , top: Belgian Malinois at < 1%.
Hereditary Vitamin D-Resistant Rickets Type II
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Pomeranian at < 1%.
Hypophosphatasia (Discovered in the Karelian Bear Dog; ALPL-related)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Karelian Bear Dog at 11.0%.
Ichthyosis (Discovered in the Great Dane; SLC27A4-related)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Great Dane at < 1%.
Juvenile Encephalopathy (Discovered in the Parson Russell Terrier)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Parson Russell Terrier at 2.2%.
Juvenile Myoclonic Epilepsy (Discovered in the Rhodesian Ridgeback; JME)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Rhodesian Ridgeback at 1.1%.
L-2-Hydroxyglutaric Aciduria (Discovered in the Staffordshire Bull Terrier)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Staffordshire Bull Terrier at 1.5%.
Lagotto Storage Disease (LSD)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Lagotto Romagnolo at 1.9%.
Lamellar Ichthyosis (LI)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Shih Tzu at < 1%.
Leonberger Polyneuropathy, Type 2 (LPN2)
Autosomal dominant (Incomplete penetrance). Observed in 1 of 266 breeds tested , top: Dachshund Miniature Shorthaired at < 1%.
Limb-girdle Muscular Dystrophy, Type 2F (Discovered in the Boston Terrier)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Boston Terrier at < 1%.
Muscular Dystrophy (Discovered in the Golden Retriever)
X-linked recessive. Observed in 1 of 266 breeds tested , top: Golden Retriever at < 1%.
Muscular Hypertrophy (Double Muscling)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Greyhound at < 1%.
Neonatal Encephalopathy with Seizures (NEWS)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Poodle Standard at < 1%.
Neuroaxonal Dystrophy (Discovered in the Papillon; PLA2G6-related; NAD)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Papillon at < 1%.
Neuroaxonal Dystrophy (Discovered in the Spanish Water Dog; NAD)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Lagotto Romagnolo at < 1%.
Paroxysmal Dyskinesia (Discovered in the Irish Soft Coated Wheaten Terrier; PIGN-related; PxD)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Soft Coated Wheaten Terrier at 3.1%.
Progressive Early-Onset Cerebellar Ataxia (Discovered in the Finnish Hound; SEL1L-related)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Finnish Hound at 5.6%.
Progressive Retinal Atrophy (Discovered in the Basenji; SAG-related)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Basenji at 10.7%.
Progressive Retinal Atrophy, Type III (Discovered in the Tibetan Spaniel and Tibetan Terrier; PRA type III; FAM161A-related)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Tibetan Spaniel at 1.4%.
Renal Cystadenocarcinoma and Nodular Dermatofibrosis (RCND)
Autosomal dominant. Observed in 1 of 266 breeds tested , top: German Shepherd at < 1%.
Spinocerebellar Ataxia (Late-Onset Ataxia; CAPN1-related; SCA/LOA)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: Parson Russell Terrier at 6.4%.
Von Willebrand's Disease, Type 2 (vWD 2)
Autosomal recessive. Observed in 1 of 266 breeds tested , top: German Shorthaired Pointer at < 1%.
X-Linked Progressive Retinal Atrophy 1 (XLPRA1)
X-linked recessive. Observed in 1 of 266 breeds tested , top: Siberian Husky at < 1%.