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Leg Length

FGF4_retrogene_CFA12

chr12:34,964,869-34,964,869 · UU_Cfam_GSD_1.0

chondrodystrophy insertion site; not annotated as gene

Atlas-wide
Frequency
80%
dog-weighted average
Breeds with data
208
of 215
Dogs contributing
13,523
CanVAS Atlas
What the frequency means

The second FGF4 retrogene on chromosome 12.

High frequency means

breed does NOT carry the second FGF4 retrogene (alt allele convention as for CFA18)

Low frequency means

breed carries the FGF4 chr12 retrogene (Brown 2017) - linked to chondrodystrophy and intervertebral disc disease (Hansen Type 1)

Top 10 breeds, highest frequency
  1. Afghan Hound hound
    100% n=21
  2. Airedale Terrier terrier
    100% n=18
  3. Bedlington Terrier terrier
    100% n=11
  4. Belgian Sheepdog herding
    100% n=15
  5. Bloodhound hound
    100% n=18
  6. Bouvier Des Flandres herding
    100% n=16
  7. Boxer working
    100% n=192
  8. Bullmastiff working
    100% n=31
  9. Cane Corso working
    100% n=18
  10. Dogue De Bordeaux other
    100% n=9
Bottom 10 breeds, lowest frequency
  1. English Cocker Spaniel sporting
    0% n=39
  2. Beagle hound
    0% n=46
  3. Cavalier King Charles Spaniel toy
    1% n=102
  4. American Cocker Spaniel sporting
    2% n=67
  5. Village Dog Nz Mid ancient_landrace
    10% n=10
  6. Pembroke Welsh Corgi herding
    10% n=24
  7. Minature Poodle non_sporting
    13% n=8
  8. Basset Hound hound
    15% n=34
  9. Miniature Schnauzer terrier
    15% n=62
  10. Dachshund hound
    18% n=97
Methodology

Frequency is measured at the typed-backbone 12:34964869 on chr12, 35.0 Mb (inside the gene body). Alleles T/C. Coordinates from manual position (Ensembl symbol failed). Per-breed frequencies are computed across all CanVAS dogs labelled with that breed (missing genotypes excluded). See methodology for the full pipeline.

Last updated
Sources: CanVAS (Brundage 2026) · OMIA · Dog10K (Meadows 2023)