Skip to main content
snıff
Leg Length

FGF4_retrogene_CFA12

chr12:34,964,869-34,964,869 ·

chondrodystrophy insertion site; not annotated as gene

Atlas-wide
80%
dog-weighted average
Breeds with data
208
of 215
Dogs contributing
13,523
CanVAS Atlas
What the frequency means

The second FGF4 retrogene on chromosome 12.

High frequency means

breed does NOT carry the second FGF4 retrogene (alt allele convention as for CFA18)

Low frequency means

breed carries the FGF4 chr12 retrogene (Brown 2017) - linked to chondrodystrophy and intervertebral disc disease (Hansen Type 1)

Frequency landscape

Where the leg length variant sits across every breed with data, by and grouped by . Each tick is one breed; a variant fixed in one group and absent in another shows up as a gap. These come from one marker per trait, so read them as a : accurate for most breeds, with real exceptions.

0%50%100%
terrier22 breeds · mean 82%
working21 breeds · mean 81%
other16 breeds · mean 80%
herding16 breeds · mean 79%
ancient_landrace51 breeds · mean 78%
toy18 breeds · mean 70%
mixed_unknown3 breeds · mean 69%
non_sporting22 breeds · mean 68%
sporting19 breeds · mean 63%
hound20 breeds · mean 62%
n = 13,523 dogs · CanVAS Atlas (Brundage et al. 2026) · Sniff Atlas
Allele frequency across 208 breeds with data, grouped by AKC breed group. Each accent tick is one breed (fainter = fewer dogs sampled); the bone marker is the group mean. Frequencies are population-level.
Top 10 breeds, highest frequency
  1. Boxer working
    100% n=192
  2. Norfolk Terrier terrier
    100% n=32
  3. Bullmastiff working
    100% n=31
  4. Pug toy
    100% n=31
  5. Irish Setter sporting
    100% n=23
  6. Otterhound hound
    100% n=23
  7. Afghan Hound hound
    100% n=21
  8. Golden Retriever sporting
    99% n=3523
  9. Mastiff working
    98% n=32
  10. 97% n=31
Bottom 10 breeds, lowest frequency
  1. 0% n=39
  2. Beagle hound
    0% n=46
  3. 1% n=102
  4. 2% n=67
  5. 10% n=24
  6. Basset Hound hound
    15% n=34
  7. 15% n=62
  8. Dachshund hound
    18% n=97
  9. French Bulldog non_sporting
    21% n=41
  10. Pekingese toy
    27% n=26

105 breeds with fewer than 20 genotyped dogs are not ranked here. At that sample size a single dog swings the frequency, so the figure is not yet stable enough to compare.

Methodology

Frequency is measured at the typed-backbone 12:34964869 on chr12, 35.0 Mb (inside the gene body). Alleles T/C. Coordinates from manual position (Ensembl symbol failed). Per-breed frequencies are computed across all CanVAS dogs labelled with that breed (missing genotypes excluded).

How to cite this page

The per-breed allele frequencies on this page are derived from the open Sniff Atlas v1.0.1 (Gehring 2026, doi:10.5281/zenodo.20566358, CC-BY 4.0). The underlying genotype substrate is CanVAS (Brundage 2026, doi:10.64898/2026.04.13.718238), and disease associations are grounded in OMIA. Full citation formats including BibTeX, RIS, and CITATION.cff at sniff.world/cite.

Last updated
Sources: Sniff Atlas v1.0.1 (doi:10.5281/zenodo.20566358) · CanVAS (Brundage 2026) · OMIA · Dog10K (Meadows 2023)