NDRG1
NDRG1 is a gene catalogued in the canine genome. Below are the inherited conditions OMIA links to it in dogs, its human counterpart, and its canonical records across the genomics world.
The inherited conditions OMIA associates with NDRG1 in dogs. Each links to the full record.
NDRG1 as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.
In humans, this gene's counterpart is NDRG1. That ortholog is what connects NDRG1 to a century of human medical genetics. The dog and human proteins are 81% identical.
In people, NDRG1 appears tolerant of loss-of-function variation (gnomAD v4.1 constraint, LOEUF 0.72). Constraint measures intolerance to loss-of-function only and does not indicate importance; some tolerant genes cause disease through other mechanisms.
In people, variants in the NDRG1 gene have conflicting classifications in ClinVar, and none is expert-reviewed. The evidence is unsettled, not that variants here are benign.
The dog side carries more cited disease evidence than the human side. This is unaudited: it can mean the dog literature is genuinely ahead, or that our human ingestion is still incomplete. It is a lead to check, not a conclusion. Coverage, not importance. D = 1 dog vs H = 0 human cited disease channels.
Lookup and discovery are candidate-framed research surfaces. Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.
Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For NDRG1 we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.
Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.