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Canine gene

SOD1

Human counterpart: SOD1

SOD1 is a gene catalogued in the canine genome. Below are the inherited conditions OMIA links to it in dogs, its human counterpart, and its canonical records across the genomics world.

Conditions linked to this gene

The inherited conditions OMIA associates with SOD1 in dogs. Each links to the full record.

In the reference databases

SOD1 as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.

The human counterpart

In humans, this gene's counterpart is SOD1. That ortholog is what connects SOD1 to a century of human medical genetics. The dog and human proteins are 81% identical (a lower-confidence 1:1 call, shown for transparency, not hidden).

In people, SOD1 appears tolerant of loss-of-function variation (gnomAD v4.1 constraint, LOEUF 1.51). Constraint measures intolerance to loss-of-function only and does not indicate importance; some tolerant genes cause disease through other mechanisms.

In people, variants in the SOD1 gene have conflicting classifications in ClinVar, and none is expert-reviewed. The evidence is unsettled, not that variants here are benign.

In dogs, 5 of 286 Dog10K variants in this gene sit at a position kept conserved across 241 mammals (the exhaustive scan), candidates worth a closer look, never a diagnosis.

Translational evidence balance
dog-ahead (unaudited) · +1

The dog side carries more cited disease evidence than the human side. This is unaudited: it can mean the dog literature is genuinely ahead, or that our human ingestion is still incomplete. It is a lead to check, not a conclusion. Coverage, not importance. D = 1 dog vs H = 0 human cited disease channels.

Medicine face

Q1 · both planes filled

SOD1

Two planes on one gene. Disagreement is the reading, not a hole to fill.A teaching case. Both the canine evidence plane and the human medicine plane hold a row.

Canine plane

Coverage

dark · below bar

lit_any

Spectra

5 named streams agree. A recount, not a medicine vote.

Open Spectra

Lookup · Discovery · Frontier

Lookup cleared (human P/LP signal exists below the 3-star expert-review bar; moderate-confidence anchor (Landrum et al. 2018)). Discovery recovered known. A candidate never fills a drug row. Frontier cause below bar.

Medicine plane

Mechanism

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Full function description, 1 more sentences
  • Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying H2S and limiting the accumulation of reactive sulfur species (RSS) such as persulfides and polysulfides.

Source UniProt via Open Targets · PMID 18948262 · PMID 24140062 · PMID 36630448

Platelet degranulation · Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation · Detoxification of Reactive Oxygen Species · Reactome

Molecules

  • Qalsody, generically Tofersen

    APPROVAL

    ANTISENSE INHIBITOR · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

    Labeled for amyotrophic lateral sclerosis, the parent term of amyotrophic lateral sclerosis type 1.

Canine trials

unqueryable

We hold no canine registry row. The AVMA Veterinary Clinical Trials Registry is the index that would hold one. This station is unqueryable until that ingest exists. That is not evidence that nobody runs trials in dogs.

PK / tox station

stub

This station is not wired. No PK or tox numbers.

This is not a treatment recommendation and not a claim about any individual dog.

Molecule direction and mechanism of action include ChEMBL (CC BY-SA 3.0).

Coverage · Spectra · Frontier

Research tools for this gene
Dog10K lookup Candidate models AVCG classification table

Lookup and discovery are candidate-framed research surfaces. Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.

On the numbers

Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For SOD1 we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.

How to cite this page

Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.

Last updated
Sources: OMIA · Sniff gene crossrefs · Ensembl / NCBI / HGNC · gnomAD v4.1 (Karczewski 2020) · ClinVar (Landrum 2018) · Dog10K (Meadows 2023) · Zoonomia 241-way phyloP (Christmas 2023)