VWF
VWF is a gene catalogued in the canine genome. Below are the inherited conditions OMIA links to it in dogs, its human counterpart, and its canonical records across the genomics world.
The inherited conditions OMIA associates with VWF in dogs. Each links to the full record.
VWF as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.
- NCBI Gene 399544
- Ensembl ENSCAFG00000015228
- RefSeq NP_001002932.1
- OMIA disease OMIA:001057-9615
- OMIA disease OMIA:001058-9615
- OMIA disease OMIA:001339-9615
In humans, this gene's counterpart is VWF. That ortholog is what connects VWF to a century of human medical genetics. The dog and human proteins are 86% identical.
In people, VWF appears tolerant of loss-of-function variation (gnomAD v4.1 constraint, LOEUF 0.64). Constraint measures intolerance to loss-of-function only and does not indicate importance; some tolerant genes cause disease through other mechanisms.
In people, variants in the VWF gene are classified as pathogenic in ClinVar for 9 expert-reviewed conditions.
Dog and human evidence are symmetric here, a validated cross-species footprint. Coverage, not importance. D = 1 dog vs H = 1 human cited disease channels.
Lookup and discovery are candidate-framed research surfaces (7 surfaced Dog10K candidates name this gene; never confirmed). Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.
Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For VWF we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.
Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.