Skip to main content
snıff

Reverse query / human → dog

X-linked Alport syndrome.

X-linked form of Alport syndrome.

Which dogs are a natural model of this human disease. Each row is a distinct gene pathway with a canine model, ranked by evidence strength. We assert the canine disease models the human one (gene-level), never that a dog allele equals a human variant.

1 model pathways 1 OMIA-anchored MONDO:0010520 ↗
Canine model pathway Evidence Ortholog Human anchor Canine variant · assembly
COL4A5 → COL4A5 OMIA model-of OMIA-anchored one_to_one — gene-level (no single variant)
The boundary of this model. These are the characterized pathways, human genes of this disease that have a canine model in our substrate. A human disease can involve genes with no canine model yet; enumerating those unmapped pathways as explicit abstentions lands with the ClinGen / GenCC human gene-disease validity map (Phase 2). Until then we show what we hold and state that it may be incomplete, rather than imply full coverage.
A candidate model is a computational hypothesis (gene-level model-of, INV-57), never a confirmed model; confirmation is DNA plus phenotype, in the lab. Canine coordinates are on UU_Cfam_GSD_1.0 and carry their assembly (no cross-assembly comparison without a scored liftover). Sources: OMIA, ClinVar (Landrum 2018), Ensembl Compara orthology, Mondo. Ranked by evidence strength within this human disease.