Cancer-driver node · fused signature
ARPC1A
Every register Sniff holds about ARPC1A, in one place, each strand cited to its source. This is a gene-level, model-of view of somatic cohort frequencies and human evidence, never a germline carrier status for an individual dog and never a per-dog prediction.
Somatic driver in canine cancer
The fraction of sequenced tumors somatically altered in ARPC1A, per cancer, from peer-reviewed cohorts. A cohort rate, not an individual-dog risk. Each cancer carries its cross-species concordance: whether the dog and human agree on this driver (commensurability-gated, INV-81).
Human constraint
LOEUF 0.31
constrained (LoF-intolerant) · gnomAD v4.1
Germline (human)
no germline syndrome (a true negative, not a gap)
Dog↔human ortholog
high-corroborated
4 methods · 100% identity