Cancer-driver node · fused signature
PTPN11
Every register Sniff holds about PTPN11, in one place, each strand cited to its source. This is a gene-level, model-of view of somatic cohort frequencies and human evidence, never a germline carrier status for an individual dog and never a per-dog prediction.
Somatic driver in canine cancer
The fraction of sequenced tumors somatically altered in PTPN11, per cancer, from peer-reviewed cohorts. A cohort rate, not an individual-dog risk. Each cancer carries its cross-species concordance: whether the dog and human agree on this driver (commensurability-gated, INV-81).
The human literature carries more cited disease evidence than the dog side. A study gap on the canine side. Coverage, not importance. D = 1 dog vs H = 2 human cited disease channels.
Germline hereditary-cancer syndromes (human)
GERMLINE variants in PTPN11 that cause human hereditary-cancer syndromes (ClinVar, 3-star expert-reviewed). This is a separate register from the somatic tumor drivers above, the same gene in two distinct biologies (INV-65). Each links to its Monarch/Mondo record.