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Canine gene

DMD

Human counterpart: DMD

DMD is a gene catalogued in the canine genome. Below are the inherited conditions OMIA links to it in dogs, its human counterpart, and its canonical records across the genomics world.

Conditions linked to this gene

The inherited conditions OMIA associates with DMD in dogs. Each links to the full record.

In the reference databases

DMD as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.

The human counterpart

In humans, this gene's counterpart is DMD. That ortholog is what connects DMD to a century of human medical genetics. The dog and human proteins are 95% identical.

In people, variants in the DMD gene have conflicting classifications in ClinVar, and none is expert-reviewed. The evidence is unsettled, not that variants here are benign.

Translational evidence balance
dog-ahead (unaudited) · +0.333

The dog side carries more cited disease evidence than the human side. This is unaudited: it can mean the dog literature is genuinely ahead, or that our human ingestion is still incomplete. It is a lead to check, not a conclusion. Coverage, not importance. D = 2 dog vs H = 1 human cited disease channels.

Cancer-driver signature

DMD is a fused cancer-driver node. See its somatic role across canine cancers, human gnomAD constraint, germline ClinVar syndromes, and the dog-human ortholog in one cited view. Open the driver node →

Medicine face

Q1 · both planes filled

DMD

Two planes on one gene. Disagreement is the reading, not a hole to fill.A teaching case. Both the canine evidence plane and the human medicine plane hold a row.

Canine plane

Coverage

dark · below bar

lit_any

Spectra

6 named streams agree. A recount, not a medicine vote.

Open Spectra

Lookup · Discovery · Frontier

Lookup abstained (human P/LP signal exists below the 3-star expert-review bar; moderate-confidence anchor (Landrum et al. 2018)). Discovery recovered known. A candidate never fills a drug row. Frontier cause below bar.

Medicine plane

Mechanism

Anchors the extracellular matrix to the cytoskeleton via F- actin.

Full function description, 3 more sentences
  • Ligand for dystroglycan.
  • Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma.
  • Also implicated in signaling events and synaptic transmission.

Source UniProt via Open Targets · PMID 16710609

Formation of the dystrophin-glycoprotein complex (DGC) · Striated Muscle Contraction · Non-integrin membrane-ECM interactions · Reactome

Molecules

  • Elevidys, generically Delandistrogene Moxeparvovec-Rokl

    APPROVAL

    EXOGENOUS GENE · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

  • Amondys 45, generically Casimersen

    APPROVAL

    POSITIVE MODULATOR · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

    Labeled for Duchenne muscular dystrophy.

  • Drisapersen

    PHASE 3

    POSITIVE MODULATOR · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

    Labeled for Duchenne muscular dystrophy.

  • Eteplirsen

    APPROVAL

    POSITIVE MODULATOR · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

    Labeled for Duchenne muscular dystrophy.

More molecule rows are held. This face does not print an approved-drug count.

Canine trials

unqueryable

We hold no canine registry row. The AVMA Veterinary Clinical Trials Registry is the index that would hold one. This station is unqueryable until that ingest exists. That is not evidence that nobody runs trials in dogs.

PK / tox station

stub

This station is not wired. No PK or tox numbers.

This is not a treatment recommendation and not a claim about any individual dog.

Molecule direction and mechanism of action include ChEMBL (CC BY-SA 3.0).

Coverage · Spectra · Frontier

Research tools for this gene
Dog10K lookup Candidate models AVCG classification table

Lookup and discovery are candidate-framed research surfaces. Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.

On the numbers

Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For DMD we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.

How to cite this page

Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.

Last updated
Sources: OMIA · Sniff gene crossrefs · Ensembl / NCBI / HGNC · ClinVar (Landrum 2018)