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Reverse bridge / human → dog

Canine natural models of human disease.

The dog is one of medicine's most powerful natural models: it shares our homes, our environment, and much of our genome, and it develops many of the same diseases spontaneously. This is the reverse of the usual bridge. Start from a human disease and see which dogs carry a natural model of it, mapped gene by gene across the ortholog bridge, ranked by evidence, and cited.

344 human diseases mapped 262 with an OMIA-anchored model

Each entry is a candidate model: a computational hypothesis (gene-level model-of, INV-57), never a confirmed model. Confirmation is DNA plus phenotype, in the lab. Ranked by OMIA-anchored evidence first. Sources: OMIA (Nicholas, Tammen, CC-BY), ClinVar (Landrum 2018), Ensembl Compara orthology, Mondo. Every claim cited, or it says it does not know.