GRLS Hero Oldie · Founder

Oldies_grls65978e8a

Oldies_grls65978e8a is a Golden Retriever from the GRLS research cohort. One of 14,478 dogs who built the atlas.

About this name and portrait

I'm sure you probably guessed by now. These aren't real pictures of these dogs. And these aren't their real names.

But these dogs were real. They were alive. They were loved. We thought they deserved more than a subject ID to be remembered by. The portraits are built from each dog's actual genome, so we tried to get it close. But it's not enough.

We want to see your dog's face. We want to celebrate them by the name they were loved by. We want to look back and say 'oh yeah, Bosco? The Dachshund-Corgi mix? I remember him, his FGF4 variant was wild, those little legs could hold a small house.'

These dogs gave something most people don't realize. The Heroes in the Golden Retriever Lifetime Study showed up for blood draws, health surveys, fur and nail samples, every single year. Some of them for 14 years. Their data has taught us about lymphoma, hemangiosarcoma, and aging in ways that help not just dogs but potentially humans. And they didn't ask for any of it.

Morris Animal Foundation calls them Heroes. We agree.

If your dog was part of any of these studies, we want to give you their page. Their real name. Their real photo. The recognition they earned.

Email [email protected].

About Oldies_grls65978e8a

Oldies_grls65978e8a sits well inside the Golden Retriever cluster - a fairly typical example.

Predicted large by the six body-size genes the atlas reads (IGF1, HMGA2, SMAD2, LCORL, STC2, ADAMTS17).
Standard leg length. No chondrodysplasia retrogene variant.
Carrier of the RSPO2 wire-coat variant (single copy).

Oldies_grls65978e8a's nearest neighbors

The five dogs in the atlas whose genomes sit closest to Oldies_grls65978e8a's. Click any of them to keep exploring.

Oldies_grls65978e8a's breed

Oldies_grls65978e8a sits in the Golden Retriever cluster, with genome overlap to Labrador Retriever - sister breeds nearby in the atlas.

Breed similarity from non-negative least squares against 91 breed centroids in PCA-256 space, corrected for atlas sample-size imbalance. Without correction, Goldens (22% of the atlas) leak into every dog's raw NNLS breakdown; with it, the bias falls out. Raw fractions stay in the dataset for re-derivation. Methodology.

Golden Retriever 83%
Labrador Retriever 17%

Source

From the Golden Retriever Lifetime Study . Breed-page reference: Golden Retriever.

Full genotype detail

click to expand

The actual allele call at each locus's representative SNP for this dog. Each gene name links to its page where you can see the per-breed frequency table and the direction of effect.

Body size

IGF1	C/A
HMGA2	T/T
SMAD2	G/G
LCORL	G/G
STC2	A/A
ADAMTS17	G/G

Leg length

FGF4·CFA18	C/C
FGF4·CFA12	C/C

Coat

RSPO2	C/T
FGF5	T/C
KRT71	C/C
MC1R	T/T

Ear set

MSRB3

A/A

Skull shape

BMP3	C/T
SMOC2	G/G

Technical details

click to expand

The numbers behind the placement. Useful for researchers reproducing the math or debugging an unexpected position; not interesting to most readers.

UMAP-3D position

x 8.214
y 9.568
z 7.882

PCA-256 distance from breed centroid

32.89

Outlier percentile in breed

lower = more typical

Top-3 principal components by |z|

The 3 PCs on which Oldies_grls65978e8a scores most extreme, with the 3 highest-loading SNPs on each. Foundation for the future genome-ring visualization.

PC66 z = -3.44

chr22:1,996,400 loading 0.0426
chr22:1,969,643 loading -0.0423
chr22:2,473,315 loading 0.0395

PC111 z = -2.93

chr25:27,400,046 loading 0.0340
chr8:38,891,669 loading -0.0320
chr6:31,045,365 loading -0.0319

PC126 z = -2.77

chr21:31,645,739 loading 0.0387
chr21:34,014,573 loading -0.0385
chr26:6,573,837 loading 0.0382

Ancestry reconstruction error: 0.57

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