CoverageFrame · composition

Does any scoped source document a canine model foundation for this human disease gene?

One frame is a measurement of one source. Several frames over the same subject axis is a map. Dark in every frame is the unexamined set.

Release sniff:release/2026-09-04 · ClinVar last updated 2026-08-13 · OMIA last updated 2026-08-27 · schema · frame JSON

ClinVar 3-star + ortholog

124 lit

16,630 dark under this lens

last updated 2026-08-13

OMIA canine disease-gene

183 lit

16,571 dark under this lens

last updated 2026-08-27

dark_in_all_frames

16,462

15 lit_all · 277 lit_any

Under ClinVar 3-star + ortholog and OMIA canine disease-gene only. Sources outside this stack are not evaluated.

What each frame measures

This frame stacks scoped source-frames over one subject axis. A cell is answered when any constituent is lit, and dark when every constituent of this stack is dark. dark_in_all_frames is scoped to the named constituents, not to the world. Causes stay on the constituents.

ClinVar 3-star + ortholog

This frame measures ClinVar 3-star review reach into canine models via dog orthology, not the canine literature.

infores:clinvar, infores:ensembl-gene

last updated 2026-08-13

OMIA canine disease-gene

This frame measures OMIA's documented canine Mendelian disease-gene reach into the same human-disease-gene universe. It is not ClinVar, and it is not a combined census.

infores:omia

last updated 2026-08-27

ClinVar lens (causes are this frame's)

expected cells

16,754

Human disease genes touched by the dog-to-human bridge

answered

124

a cited assertion exists

dark

16,630

each cell carries one cause

answered 124

no_disease_anchor 11,161

below_bar 5,362

unreachable 107

no_disease_anchor 11,161
below_bar 5,362
unreachable 107
method_limited 0
No cells in this frame. The enum still carries the term.
absent 0
No cells in this frame. The enum still carries the term.
unstudied 0
No cells in this frame. The enum still carries the term.

Ask a cell

Three outcomes, never silence: answered, dark with a cause, or not in this question space. Same object the MCP tool lookup_canine_model returns.

Gene symbol

walk:

The procedure behind the no

A cell is answered when the human gene has a 3-star ClinVar P/LP anchor AND an assertable dog ortholog (Compara one2one, or the OrthoDB/OMA moderate ladder for reachability). Dark causes per the precedence funnel; below_bar is denominated by the named dial.

completeness: exhaustive
cause precedence: unreachable → method_limited → no_disease_anchor → unstudied → below_bar → absent

Populations

sniff:population/bridge-touched-human-genes@2 · n=16,754 Every human gene touched by the dog-to-human bridge: ClinVar P/LP disease-gene atoms (3-star anchors kept, below-expert-bar signal retained as below_bar) joined to the dog orthology ladder; the human-gene selection funnel total (the human-gene selection funnel total).
sniff:population/canine-one2one-ortholog-space@2 · n=17,239 Dog genes with ortholog_status=one2one in the Ensembl Compara one-to-one set; the moderate OrthoDB/OMA ladder used for reachability is stated in match_criteria, not double-counted here.

Positive controls

A protocol that cannot find what is independently known to exist does not publish its dark cells.

gene	expected	observed	basis
TP53	answered	answered	TP53: OMIA:000620-9615 (histiocytic sarcoma), canine, listed by OMIA among the genes associated with this phene, independent of this pipeline. Weaker anchor than F8 and VWF: OMIA records this phene as multifactorial with no key variant known, and removed its candidate variant from the table of likely causal variants. Retained as a control on the recorded association, not on a causal variant.
F8	answered	answered	F8: OMIA:000437-9615 (hemophilia A), canine, documented independent of this pipeline
VWF	answered	answered	VWF: OMIA:001057-9615 (von Willebrand disease), canine, documented independent of this pipeline

The world moved

Kind frame_moved · sniff:delta/2026-09-03..2026-09-04

delta JSON

The schema this fills in

Three small LinkML modules. The census, the recipe, the change log. A CoverageFrame is a companion InformationContentEntity, not an Association mixin. Inspect the form, then the filled-in values above.

Human-readable schema index
sniff-coverage-frame.yaml · CoverageFrame, FrameCell, DarkCauseEnum
sniff-coverage-frame-provenance.yaml · SearchProtocol, PopulationDefinition, PositiveControl
sniff-coverage-frame-delta.yaml · FrameDelta, CellTransition

Query the same object

REST /api/v1/coverage/model_of.json?gene=SOD1
MCP lookup_canine_model and agent_discover at POST /api/mcp
Frame declaration /api/v1/coverage/frames.json